hepatoprotective effect of otostegia persica boiss. shoot extract on carbon tetrachloride-induced acute liver damage in rats

نویسندگان

sedighe nasiri bezenjani department of biology, school of sciences, shahid bahonar university of kerman, kerman, iran.

iran pouraboli department of biology, school of sciences, shahid bahonar university of kerman, kerman, iran.

reza malekpour afshar research center of physiology, kerman university of medical sciences, kerman, iran.

gholamabbas mohammadi department of biochemistry, medical school of afzalipour, kerman university of medical sciences, kerman, iran.

چکیده

in this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from otostegia persica boiss (golder) was investigated against the carbon tetrachloride (ccl4)-induced acute hepatotoxicity in male rats. liver damage was induced through the oral administration of 50% ccl4 in liquid paraffin (2.5 ml/kg bw, per os) 60 min after the administration of the methanol extract of o. persica shoot (in 200, 300, 400 mg/kg bw doses) and assessed using biochemical parameters (plasma and liver tissue malondialdehyde (mda), transaminase enzyme levels in plasma [aspartate transaminase (ast), alanine aminotransferase (alt)] and liver glutathione (gsh) levels). results show that the methanol extract of o. persica shoot is active at 300 mg/kg (per os) and it possess remarkable antioxidant and hepatoprotective activities. additionally, histopathological studies verified the effectiveness of this dose of extract in acute liver damage prevention.

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منابع مشابه

Hepatoprotective Effect of Otostegia persica Boiss. Shoot Extract on Carbon Tetrachloride-Induced Acute Liver Damage in Rats

In this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from Otostegia persica Boiss (Golder) was investigated against the carbon tetrachloride (CCl4)-induced acute hepatotoxicity in male rats. Liver damage was induced through the oral administration of 50% CCl4 in liquid paraffin (2.5 mL/Kg bw, per os) 60 min after the administration of the methanol extract o...

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Hepatoprotective Effect of Otostegia persica Boiss. Shoot Extract on Carbon Tetrachloride-Induced Acute Liver Damage in Rats

In this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from Otostegia persica Boiss (Golder) was investigated against the carbon tetrachloride (CCl4)-induced acute hepatotoxicity in male rats. Liver damage was induced through the oral administration of 50% CCl4 in liquid paraffin (2.5 mL/Kg bw, per os) 60 min after the administration of the methanol extract o...

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Hepatoprotective Effect of Otostegia persica Boiss. Shoot Extract on Carbon Tetrachloride-Induced Acute Liver Damage in Rats

In this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from Otostegia persica Boiss (Golder) was investigated against the carbon tetrachloride (CCl4)-induced acute hepatotoxicity in male rats. Liver damage was induced through the oral administration of 50% CCl4 in liquid paraffin (2.5 mL/Kg bw, per os) 60 min after the administration of the methanol extract o...

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Hepatoprotective activity of aerial parts of Otostegia persica against carbon tetrachloride-induced liver damage in rats

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Hepatoprotective activity of aerial parts of Otostegia persica against carbon tetrachloride-induced liver damage in rats

OBJECTIVE To evaluate the hepatoprotective properties of Otostegia persica (O. persica) ethanol extract on carbon tetrachloride-induced liver damage in rats. MATERIALS AND METHODS Fifty adult male Wistar rats were randomly divided into five groups. Group I served as normal control and was given only olive oil intraperitoneally (i.p.). Group II, III, IV, and V were administered CCl4 mixed with...

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hepatoprotective activity of aerial parts of otostegia persica against carbon tetrachloride-induced liver damage in rats

objective: to evaluate the hepatoprotective properties of otostegia persica (o. persica) ethanol extract on carbon tetrachlo­­ride-induced liver damage in rats. materials and methods: fifty adult male wistar rats were randomly divided into five groups. group i served as normal control and was given only olive oil intraperitoneally (i.p.). group ii, iii, iv, and v were administered ccl4 mixed wi...

متن کامل

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عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۱۱، شماره ۴، صفحات ۱۲۳۵-۱۲۴۱

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